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Research on OPC and Capilliary Resistance


All blood vessels in the body, arteries, veins and capillaries, transport blood around the body. Blood carries oxygen and nutrients to the cells, and carries waste products away from them. The vascular system is a highly branched set of tubes that carry the blood to all parts of the body. Blood pressure results from the pumping of the heart, and affects the movement of fluids throughout the vascular system.

Fluids move through blood vessels (as with any kind of pipe) when there is a pressure difference between the start and end of the pipe. Just as water moves continuously downhill as a river flows, the pressure drops continuously from the start to the end of a vessel. Since the capillaries are (in a sense) midway between arteries and veins, their pressure will be lower than the central arterial pressure and higher than the central venous pressure. Also, within the capillaries themselves, the pressure will gradually drop from their arteriolar side to their venule side.

When a much bigger resistance to flow is introduced in the middle of this pipe (like a damn built on a river, or a "squeeze" on a tube), the pressure upstream from that resistance will be closer to that near the beginning of the pipe, and the pressure downstream will be closer to that near the end.1

19802 – OPC was tested in a double blind study on a group of elderly people who, either spontaneously or by means of a dosage of one gram acetyl-salicylic acid per day, had a very low capillary resistance.

For the whole group treated with 100 to 150 mg of OPC per day, the following results were obtained:

Tremendous improvement20%
Significant improvement53%
Reasonable improvement 6%
No change27%

After approximately three weeks, the maximum attainable result was reached for all patients.2

19803 – OPC was tested in a double blind study on a group of elderly people who had a very low capillary resistance. In ten of the twenty-one cases, OPC appeared to work efficiently by administering them 100mg of OPC per day.

The researchers concluded that they achieved improved capillary resistance and permeability in this group of elderly people, without inducing pathological changes in the microcirculation.3

19814 – Capillary resistance was tested (via double blind testing) in two groups of people averaging 46 years of age. They were administered 150mg of OPC. In one group capillary resistance increased from 15.4 to 18.1 cm Hg and in the other (double blind test) group it increased from 14.8 to 18 cm Hg.4

19835 – One of the complications encountered in patients who suffer from cirrhosis of the liver is increased risk of bleeding. The effectiveness of OPC on improving capillary resistance was tested (double-blindly) on a group of cirrhosis sufferers. The researchers reported that with a dosage of 300mg of OPC per day, they significantly improved capillary fragility without varying the biological hepatic parameters.5

  1. Patlak, J. (1999). Understanding how changing resistance changes capillary pressures. http://physioweb.med.uvm.edu/bodyfluids/capillar.htm. Retrieved 12 Oct 2008.(return)
  2. Bobos, G., Durst, G. & Hogonot, R. (1980). Evolution de la résistance capillaire, spontanément ou artificiellement diminuée par l’action d’une substance capillaro-toxique chez des personnes âgées. La Revue de la Griatrie, Tome 5, no 6, Septembre 1980.(return)
  3. Dartenuc, J., Marache, P. & Choussat, H. (1980). Résistance capillarie en gériatrie. Etude d’un microangioprotecteur = Endotelon [medical OPC product]. Bordeaux Médical, 1980; 13: 903-7.(return)
  4. Lagrue, G., Olivier-Matin, F. & Grillot, A. (1981). Etude des effets des oligomères du procyanidol sur le résistance capillaire dans l’hypertension artérielle et certaines néphropathies. Sem. Hop. Paris, 18-25 septembre, 1981.(return)
  5. Lesbre, F. & Tigaud, J. (1983). Effet de l’Endotélon sur l’indice de fragilité capillaire dans une polupation spécifique: le sujets cirrhotiques. Gaz. Med. De France – 90, no 24 du 24-VI-1983.(return)

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Enjoy Life health & wellbeing
Enjoy Life health & wellbeing